%0 Journal Article
%T A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
%A Guillaume Marti
%A V¨¦ronique Eparvier
%A Marc Litaudon
%A Philippe Grellier
%A Fran£¿oise Gu¨¦ritte
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15107106
%X Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
%K Rheedia acuminata
%K Clusiaceae
%K xanthones
%K antiplasmodial activity
%K cytotoxicity
%U http://www.mdpi.com/1420-3049/15/10/7106