%0 Journal Article
%T The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet
%A Yu Yang
%A Jiazheng Jiang
%A Luobu Qimei
%A Xiaojing Yan
%A Junxia Zhao
%A Huizhu Yuan
%A Zhaohai Qin
%A Mingan Wang
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15107075
%X A new C9 monoterpenoid acid (litseacubebic acid, 1) and a known monoterpene lactone (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide (2), along with three known compounds ¨C vanillic acid (3), trans-3,4,5-trimethoxylcinnamyl alcohol (4), and oxonantenine (5) ¨C were isolated with bioassay-guided purification from the fruit extract of Litsea cubeba collected in Tibet. The structure of 1 was elucidated by MS, 1H-NMR, 13C-NMR, COSY, HSQC, HMBC, NOE spectral data as 2,6-dimethyl-6-hydroxy-2E,4E-hepta-2,4-diene acid. Additionally 33 compounds were identified from the essential oil of L. cubeba. The preliminary bioassay results showed that 1 and 2 have good fungicidal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris, Pseudocer-cospora musae and Colletotrichum gloeosporioides at the concentration of 588 and 272 ¦ÌM, and the essential oil has good fungicidal activities against T. cucumeris and S. sclerotiorum, with IC50 values of 115.58 and 151.25 ¦Ìg/mL, repectively.
%K Litsea cubeba
%K Lauraceae
%K (6R)-3
%K 7-dimethyl-7-hydroxy-2-octen-6-olide
%K litseacubebic acid
%K essential oil
%K fungicidal activity
%U http://www.mdpi.com/1420-3049/15/10/7075