%0 Journal Article
%T Synthesis and Anti-Hyperlipidemic Evaluation of N£¿(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats
%A Ghassan Shattat
%A Rania Al-Qirim
%A Yusuf Al-Hiari
%A Ghassan Abu Sheikha
%A Tariq Al-Qirim
%A Waseem El-Huneidi
%A Moyad Shahwan
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15095840
%X The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.
%K Triton WR-1339-induced hyperlipidemic rats
%K N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides
%K high-density lipoprotein-cholesterol
%K triglycerides
%K hypolipidemic activity
%U http://www.mdpi.com/1420-3049/15/9/5840