%0 Journal Article
%T Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)
%A Rita R. Kurdelas
%A Beatriz Lima
%A Alejandro Tapia
%A Gabriela Egly Feresin
%A Manuel Gonzalez Sierra
%A Mar¨ªa Victoria Rodr¨ªguez
%A Susana Zacchino
%A Ricardo D. Enriz
%A Monica L. Freile
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15074898
%X The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5¡¯-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5¡¯-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 ¦Ìg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 ¦Ìg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 ¦Ìg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
%K Baccharis darwinii
%K Asteraceae
%K prenylated coumarins
%K auraptene
%K antimicrobial activity
%U http://www.mdpi.com/1420-3049/15/7/4898