%0 Journal Article
%T Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives
%A Jerzy Kossakowski
%A Mariola Krawiecka
%A Bo£żena Kuran
%A Joanna Stefa¨½ska
%A Irena Wolska
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15074737
%X Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. 1H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 mg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC ¨C 100 mg/mL).
%K 3-benzofurancarboxylic acid
%K antimicrobial activity
%K antifungal activity
%K X-ray diffraction
%U http://www.mdpi.com/1420-3049/15/7/4737