%0 Journal Article
%T Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone
%A Abdullah M. Asiri
%A Salman A Khan
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15106850
%X A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good anti-bacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one (4) and [(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)methyl]benzonitrile (5) with MIC values of 6.25 ¦Ìg/mL.
%K Schiff bases
%K aminophenazone
%K antibacterial activity
%K ciprofloxacin
%U http://www.mdpi.com/1420-3049/15/10/6850