%0 Journal Article
%T Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde
%A Jihua Wang
%A Hao Liu
%A Jianglin Zhao
%A Haifeng Gao
%A Ligang Zhou
%A Zhilong Liu
%A Yuanquan Chen
%A Peng Sui
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15085807
%X The root bark essential oil of Periploca sepium Bunge (Asclepiadaceae/ Apocynaceae) obtained by hydrodistillation was investigated by GC and GC-MS. 2-Hydroxy-4-methoxybenzaldehyde was found to be the main component (78.8% of the total) among 17 identified compounds. 2-Hydroxy-4-methoxybenzaldehyde was separated and purified by preparative thin layer chromatography, and was further identified by means of physicochemical and spectrometric analysis. Both the essential oil and 2-hydroxy-4-methoxybenzaldehyde exhibited antimicrobial activities on all test bacteria and fungi, with MBC/MFC values ranging from 125 ¦Ìg/mL to 300 ¦Ìg/mL, MIC values from 80 ¦Ìg/mL to 300 ¦Ìg/mL, and IC50 values from 63.29 ¦Ìg/mL to 167.30 ¦Ìg/mL. They also showed moderate antioxidant activity in the DPPH free radical scavenging, ¦Â-carotene bleaching and ferrozine-ferrous ions assays. The results indicated that the major portion of these antimicrobial and antioxidant activities was due to the presence of 2-hydroxy-4-methoxy-benzaldehyde in the oil, which could potentially be developed as an antimicrobial and antioxidant agent in the future.
%K Asclepiadaceae
%K Apocynaceae
%K Periploca sepium
%K essential oil
%K 2-hydroxy-4-methoxybenzaldehyde
%K antimicrobial activity
%K antioxidant activity
%U http://www.mdpi.com/1420-3049/15/8/5807