%0 Journal Article
%T Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities
%A Yu Chen
%A Hua Fan
%A Guang-zhong Yang
%A Yan Jiang
%A Fang-fang Zhong
%A Hong-wu He
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15107438
%X Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 ¦ÌM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 ¦ÌM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.
%K Xanthones
%K Garcinia xanthochymus
%K DPPH radical scavenging activity
%U http://www.mdpi.com/1420-3049/15/10/7438