%0 Journal Article
%T Analyzing dynamic properties of modules in PPI network<br>基于蛋白质网络的模块动态特性挖掘研究
%A GUO Yang
%A SHANG Xue-qun
%A LI Jing
%A <br>郭　阳
%A 尚学群
%A 李　晶
%J 计算机应用研究
%D 2012
%I 
%X Although many methods were proposed to analyze PPI network in past years, most of them are based on static network analysis framework. However, the PPI network is dynamic changing in living organisms. This paper analyzed the dynamic properties of modules in PPI network. Based on the time-series gene expression, it constructed the dynamic PPI snapshots and proposed a novel algorithm to mine functional modules in the snapshot networks. Thus, it adopted a fuzzy matching method to reveal the dynamic properties of modules. Experimental results illustrate the proposed method is helpful to analyze the dynamic properties of modules in PPI network.
%K PPI network
%K local similarity
%K functional module
%K dynamic property<br>蛋白质网络
%K 局部相关性
%K 功能模块
%K 动态特性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=8240383F08CE46C8B05036380D75B607&jid=A9D9BE08CDC44144BE8B5685705D3AED&aid=8D8174D12B4331BF0467EA31477B1B9E&yid=99E9153A83D4CB11&vid=771469D9D58C34FF&iid=59906B3B2830C2C5&sid=C4BD8271B8EC6D16&eid=8F8E010CA34E93D7&journal_id=1001-3695&journal_name=计算机应用研究&referenced_num=0&reference_num=12