%0 Journal Article
%T Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase
%A Ghadeer A.R.Y. Suaifan
%A Claire L.M. Goodyer
%A Michael D. Threadgill
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15053121
%X Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
%K nitric oxide synthase
%K iNOS
%K stimulation
%K thienylmethylthioureas
%U http://www.mdpi.com/1420-3049/15/5/3121