%0 Journal Article %T Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase %A Ghadeer A.R.Y. Suaifan %A Claire L.M. Goodyer %A Michael D. Threadgill %J Molecules %D 2010 %I MDPI AG %R 10.3390/molecules15053121 %X Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS). %K nitric oxide synthase %K iNOS %K stimulation %K thienylmethylthioureas %U http://www.mdpi.com/1420-3049/15/5/3121