%0 Journal Article
%T Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst
%A Ibtissem Jlalia
%A Claire Beauvineau
%A Sophie Beauvi¨¨re
%A Esra £¿nen
%A Marie Aufort
%A Aymeric Beauvineau
%A Eihab Khaba
%A Jean Herscovici
%A Faouzi Meganem
%A Christian Girard
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15053087
%X This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
%K click chemistry
%K Huisgen cycloaddition
%K copper (I) catalysis
%K triazoles
%K supported catalyst
%K parallel synthesis
%U http://www.mdpi.com/1420-3049/15/5/3087