%0 Journal Article
%T Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold
%A Daniel Blanco-Ania
%A Carolina Valderas-Cortina
%A Pedro H.H. Hermkens
%A Leo A.J.M. Sliedregt
%A Hans W. Scheeren
%A Floris P.J.T. Rutjes
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15042269
%X The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in compounds active in the central nervous system. The b-aryl pyrrolidines are synthesized through a three-step methodology that includes a Knoevenagel condensation reaction, a 1,3-dipolar cycloaddition reaction, and a nitrile reduction.
%K Knoevenagel condensation
%K 1
%K 3-dipolar cycloaddition
%K azomethine ylide
%K parallel synthesis
%K spiro dihydrouracils
%U http://www.mdpi.com/1420-3049/15/4/2269