%0 Journal Article
%T Controlled Release of 5-Aminosalicylic Acid (5-ASA) from New Biodegradable Polyurethanes
%A El-Refaie Kenawy
%A Salem S. Al-Deyab
%A Mohamed H. El-Newehy
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15042257
%X Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid) (ABHB), 5-[4-(hydroxyphenyl)azo] salicylic acid (HPAS), and 5-[1-hydroxynaphthyl)azo] salicylic acid (HNAS) with hexamethylenediisocyanate (HDI). All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and DSC analysis. All the synthesized azo polymers showed good thermal stability and the onset decomposition temperature of all these polymers was found to be above 195 oC under nitrogen atmosphere.The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 1.5) was investigated at body temperature (37 oC). The release rate of 5-ASA increased with increasing pH (i.e., 7.8 > 1.5).
%K 5-aminosalicylic acid
%K azo polymers
%K biodegradable polymers
%K polyurethane
%K drug delivery systems
%U http://www.mdpi.com/1420-3049/15/4/2257