%0 Journal Article
%T p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)
%A Fangfang Wang
%A Minjuan Xu
%A Qingshan Li
%A Isable Sattler
%A Wenhan Lin
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15042782
%X Four new p-aminoacetophenonic acids, named (2E)-11-(4¡ä-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4¡ä-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4¡ä-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4¡ä-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1¨C4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1¨C4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn¡¯t active against VSVG/HIV-luc pseudotyping virus.
%K p-aminoacetophenonic acids
%K endophyte
%K mangrove plant
%K Aegiceras corniculatum
%U http://www.mdpi.com/1420-3049/15/4/2782