%0 Journal Article
%T Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization
%A Mykhaylo V. Vovk
%A Oleksandr M. Pinchuk
%A Andrij O. Tolmachov
%A Andrei A. Gakh
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15020997
%X The title compounds, (4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles, were prepared in four steps starting from commercially available 4-trifluoromethoxyaniline. The pyrrole (second ring) was added in one step using the Paal-Knorr method. The thiazole (third ring) was added in three steps using chloroacylation with chloroacetonitrile followed by heterocyclization with thioamides/thioureas.
%K pyrrole
%K fluorinated heterocycles
%K Paal-Knorr reaction
%K trifluoromethoxy group
%K chain heterocyclization
%U http://www.mdpi.com/1420-3049/15/2/997