%0 Journal Article
%T Molecular Recognition Studies on Naphthyridine Derivatives
%A Jos¨¦ Carlos Iglesias-S¨¢nchez
%A Dolores Santa Mar¨ªa
%A Rosa M. Claramunt
%A Jos¨¦ Elguero
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15031213
%X The association constants Kb of three hosts I¨CIII designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1¨C5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds.
%K host-guest
%K naphthyridine
%K biotin
%K acridine
%K NMR titrations
%U http://www.mdpi.com/1420-3049/15/3/1213