%0 Journal Article %T Molecular Recognition Studies on Naphthyridine Derivatives %A Jos¨¦ Carlos Iglesias-S¨¢nchez %A Dolores Santa Mar¨ªa %A Rosa M. Claramunt %A Jos¨¦ Elguero %J Molecules %D 2010 %I MDPI AG %R 10.3390/molecules15031213 %X The association constants Kb of three hosts I¨CIII designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1¨C5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds. %K host-guest %K naphthyridine %K biotin %K acridine %K NMR titrations %U http://www.mdpi.com/1420-3049/15/3/1213