%0 Journal Article %T The Reaction of Cyanoacetylhydrazine with ¦Ø-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity %A Rafat M. Mohareb %A Abeer A. Mohamed %J Molecules %D 2010 %I MDPI AG %R 10.3390/molecules15053602 %X New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. %K hydrazide-hydrazone %K 1 %K 3 %K 4-triazine %K pyridine %K pyridazine %K antitumor %U http://www.mdpi.com/1420-3049/15/5/3602