%0 Journal Article
%T The Reaction of Cyanoacetylhydrazine with ¦Ø-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity
%A Rafat M. Mohareb
%A Abeer A. Mohamed
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15053602
%X New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
%K hydrazide-hydrazone
%K 1
%K 3
%K 4-triazine
%K pyridine
%K pyridazine
%K antitumor
%U http://www.mdpi.com/1420-3049/15/5/3602