%0 Journal Article
%T Research on robustness of PPI networks based on normalized entropy<br>基于标准结构熵的PPI网络可靠性研究*
%A LI Min
%A CHEN Jian-er
%A WANG Jian-xin
%A <br>李敏
%A 陈建二
%A 王建新
%J 计算机应用研究
%D 2009
%I 
%X Analysis of the topology characters of PPI network composed of protein-protein interactions is one of the most important issues in the post-genomic era. This paper analyzed the heterogeneity and robustness of 8 PPI networks of 7 species in DIP database by using ormalized entropy. Analysis shows that these PPI networks are all scale-free, which are robust against the random removal of not more than 10% nodes, but are vulnerable to the removal of 2% nodes of high degree.
%K system biology
%K protein-protein interaction network
%K robustness
%K lethality
%K entropy<br>系统生物学
%K 蛋白质相互作用网络
%K 鲁棒性
%K 脆弱性
%K 熵
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=8240383F08CE46C8B05036380D75B607&jid=A9D9BE08CDC44144BE8B5685705D3AED&aid=B2A0F6AB45B95BF80809CC0EE77A4F42&yid=DE12191FBD62783C&vid=96C778EE049EE47D&iid=CA4FD0336C81A37A&sid=C3BF5C58156BEDF0&eid=10F298ED9F164662&journal_id=1001-3695&journal_name=计算机应用研究&referenced_num=0&reference_num=8