%0 Journal Article
%T Synthesis of syn-¦Ã-Amino-¦Â-hydroxyphosphonates by Reduction of ¦Â-Ketophosphonates Derived from L-Proline and L-Serine
%A Mario Ord¨®£¿ez
%A Selene Lagunas-Rivera
%A Emanuel Hern¨¢ndez-N¨²£¿ez
%A Victoria Labastida-Galv¨¢n
%J Molecules
%D 2010
%I MDPI AG
%R 10.3390/molecules15031291
%X The reduction of ¦Ã-N-benzylamino-¦Â-ketophosphonates 6 and 10, readily available from L-proline and L-serine, respectively, can be carried out in high diastereoselectivity with catecholborane (CB) in THF at -78 oC to produce the syn-¦Ã-N-benzylamino-¦Â-hydroxyphosphonates 11 and 13 as a single detectable diastereoisomer, under non-chelation or Felkin-Anh model control.
%K ¦Â-ketophosphonates
%K diastereoselective reduction
%K ¦Ã-amino-¦Â-hydroxy-phosphonates
%U http://www.mdpi.com/1420-3049/15/3/1291