%0 Journal Article
%T Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury
%A Li-Yun Yao
%A Qi Lin
%A Yin-Yao Niu
%A Ke-Min Deng
%A Jian-Hua Zhang
%A Yang Lu
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14104051
%X A series of lipoamino acids were synthesized and their neuroprotective effect against brain ischemia induced by oxygen-glucose deprivation (OGD) on rat cerebral slices was evaluated. Among these compounds, N-stearoyl-L-tyrosine (4), N-stearoyl-L-serine (5) and N-stearoyl-L-threonine (6) exhibited good neuroprotective activity. We found that the neuroprotective activity of lipoamino acids depended on the acyl group, the presence of a free carboxylic function and a free hydroxyl group at the branched chain of the amino acids. The results also showed that 5 was the most active compound, protecting rat brain slices against OGD as well as hydrogen peroxide (H2O2) insult at the range of 1¨C10 M.
%K lipoamino acids
%K neuroprotection
%K brain ischemia
%K oxygen-glucose deprivation
%U http://www.mdpi.com/1420-3049/14/10/4051