%0 Journal Article
%T Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
%A Ignacio Alfredo Rivero
%A Leticia Guerrero
%A Karla Alejandra Espinoza
%A Martha Cecilia Meza
%A Jes¨²s Ram¨®n Rodr¨ªguez
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14051860
%X Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.
%K alkylation
%K quinazoline-2
%K 4-dione
%K antihypertensive activity
%K microwaves
%U http://www.mdpi.com/1420-3049/14/5/1860