%0 Journal Article
%T Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
%A Yi-Sheng Xu
%A Cheng-Chu Zeng
%A Zi-Guo Jiao
%A Li-Ming Hu
%A Ru-gang Zhong
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14020868
%X 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
%K 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives
%K HIV-1 integrase
%K Mg2+ binding
%K Aryl diketo acids
%U http://www.mdpi.com/1420-3049/14/2/868