%0 Journal Article
%T Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)
%A Juliana Aparecida Severi
%A Zeila Pinheiro Lima
%A H¨¦lio Kushima
%A Alba Regina Monteiro Souza Brito
%A Lourdes Campaner dos Santos
%A Wagner Vilegas
%A Cl¨¦lia Akiko Hiruma-Lima
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14031098
%X This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-¦Â-D-glucopyranosyl-4¡¯,2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves.
%K Mangifera indica
%K Antiulcer gastric
%K Mangiferin
%K Benzophenone
%K Phenolic compounds
%U http://www.mdpi.com/1420-3049/14/3/1098