%0 Journal Article
%T Microwave Assisted Reactions of Some Azaheterocylic Compounds
%A Gheorghita Zbancioc
%A Vasilichia Bejan
%A Marian Risca
%A Costel Moldoveanu
%A Ionel I. Mangalagiu
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14010403
%X A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.
%K Microwave N-alkylation
%K Imidazole
%K Pyrimidine
%K Pyridazine
%K Phthalazine
%U http://www.mdpi.com/1420-3049/14/1/403