%0 Journal Article
%T A New Cytotoxic Friedelane Acid ¨C Pluricostatic Acid ¨C and Other Compounds from the Leaves of Marila pluricostata
%A Dionisio A. Olmedo
%A Jos¨¦ L. L¨®pez-P¨¦rez
%A Esther Del Olmo
%A Yelkaira V¨¢squez
%A Arturo San Feliciano
%A Mahabir P. Gupta
%J Molecules
%D 2008
%I MDPI AG
%R 10.3390/molecules13112915
%X Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2¦Á,3¦Â-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI50 values from 1.2 to 3.3 ¦Ìg/mL.
%K Marila pluricostata
%K Clusiaceae
%K Triterpenoids
%K Cytotoxicity
%K 2¦Á
%K 3¦Â- dihydroxy-D:A-friedoolean-28-oic acid
%U http://www.mdpi.com/1420-3049/13/11/2915