%0 Journal Article
%T Synthesis and Structural Characterization of the 5-(2-Haloethyl)pyrimidines ¨C Hydrogen-Bonded chains in ¦Á-(1-Carbamyliminomethylene)-¦Ă-Butyrolactone
%A Tatjana Gazivoda
%A Silvana Rai£¿-Mali£¿
%A Antonija Hergold-Brundi£¿
%A Mario Cetina
%J Molecules
%D 2008
%I MDPI AG
%R 10.3390/molecules13112786
%X Three novel 5-(2-haloethyl)pyrimidine derivatives were synthesized and characterized by 1H-NMR, 13C-NMR, MS, IR spectra and elemental analysis. Iodine and chlorine atoms in the C-5 side chain were introduced by reaction of 5-(2-hydroxyethyl)pyrimidine with hydroiodic acid and phosphoryl chloride, respectively. The structure of the intermediate ¦Á-(1-carbamyliminomethylene)-¦Ă-butyrolactone was determined by X-ray crystal structure analysis. The molecule deviates very slightly from planarity. Three N£¿H¡¤¡¤¡¤O hydrogen bonds link the molecules into one-dimensional chains of edge-fused rings.
%K 5-(2-Haloethyl)pyrimidine
%K Synthesis
%K X-ray crystal structure
%K Hydrogen bonds
%U http://www.mdpi.com/1420-3049/13/11/2786