%0 Journal Article
%T Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
%A Hanan Georgey
%A Nagwa Abdel-Gawad
%A Safinaz Abbas
%J Molecules
%D 2008
%I MDPI AG
%R 10.3390/molecules13102557
%X A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
%K Quinazolin-4-(3H)-ones
%K piperazines
%K chloroacetamide
%K anticonvulsant activity
%U http://www.mdpi.com/1420-3049/13/10/2557