%0 Journal Article
%T Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator
%A Kamil Musilek
%A Kamil Kuca
%A Vlastimil Dohnal
%A Daniel Jun
%A Jan Marek
%A Vit Koleckar
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12081755
%X The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
%K Quaternary
%K alkylation
%K acetylcholinesterase
%K reactivator
%K oxime
%K nerve agents
%U http://www.mdpi.com/1420-3049/12/8/1755