%0 Journal Article
%T Unusual Reactivity Patterns of 1,3,6,8-Tetraazatricyclo-[4.4.1.13,8]-dodecane (TATD) Towards Some Reducing Agents: Synthesis of TMEDA
%A Augusto Rivera
%A Jaime Rios-Motta
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12071471
%X N,N,N £¿,N £¿-Tetramethylethylenediamine (TMEDA) can be synthesized by simple reduction of 1,3,6,8-tetraazatricyclo-[4.4.1.1.3,8]dodecane (TATD), an aminal cage type amine, with formic acid. The aminal can be converted to TMEDA in high yield very easily and in a very short time. We comment on the scope and limitations of the reduction of thisaminal and propose a possible reaction mechanism.
%K Aminals
%K TMEDA
%K aminal reduction
%K Leuckart-Wallach reaction
%U http://www.mdpi.com/1420-3049/12/7/1471