%0 Journal Article
%T Synthesis of Novel Nitro-substituted Triaryl Pyrazole Derivatives as Potential Estrogen Receptor Ligands
%A Fotini Naoum
%A Konstantinos M Kasiotis
%A Prokopios Magiatis
%A Serkos A Haroutounian
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12071259
%X Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ER¦Á and ER¦Â was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBA¦Á=5.17 and RBA¦Â=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ER¦Â binding abilities.
%K Pyrazoles
%K SERMs
%K Estrogen Receptor Binding Affinity
%U http://www.mdpi.com/1420-3049/12/7/1259