%0 Journal Article
%T An Efficient Synthesis of ¦Ã-Aminoacids and Attempts to Drive Its Enantioselectivity
%A Salvador Gil
%A Margarita Parra
%A Pablo Rodr¨ªguez
%J Molecules
%D 2008
%I MDPI AG
%R 10.3390/molecules13040716
%X Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding ¦Ã-cyanoacids, which on hydrogenation yielded ¦Ã-aminoacids. Thistwo step methodology improves upon previously described results. Poor e.e¡¯s resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amideinduction.
%K GABA
%K ¦Ã-aminoacids
%K bromoacetonitrile
%K enediolate
%K regioselectivity.
%U http://www.mdpi.com/1420-3049/13/4/716