%0 Journal Article
%T Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone
%A Qiang Yu
%A Per Carlsen
%J Molecules
%D 2008
%I MDPI AG
%R 10.3390/molecules13030701
%X Water soluble homo-base polynucleotide analogues were synthesized in whichpolyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetalformation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotideanalogs exhibited hyperchromic effects, which was not the case for the correspondinguracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotideanalogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature andmelting curves with melting points at approximately 40 oC.
%K Polynucleotide
%K Nucleoside
%K Polymer
%K PVA
%U http://www.mdpi.com/1420-3049/13/3/701