%0 Journal Article
%T Synthesis and Antiviral Bioactivities of 2-Aryl- or 2-Methyl-3-(substituted- Benzalamino)-4(3H)-quinazolinone Derivatives
%A Xingwen Gao
%A Xuejian Cai
%A Kai Yan
%A Baoan Song
%A Lili Gao
%A Zhuo Chen
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12122621
%X A simple and general method has been developed for the synthesis of various4(3H)-quinazolinone derivatives by the treatment of the appropriate 3-amino-2-aryl-4(3H)-quinazolinone with a substituted benzaldehyde in ethanol. The structures of the compoundswere characterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. The title 2-aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-quinazolinone compounds III-1~III-31 were found to possess moderate to good antiviral activity. Semi-quantitative PCR andReal Time PCR assays were used to ascertain the target of action of compound III-31against TMV. The studies suggest that III-31 possesses antiviral activity due to inductionof up-regulation of PR-1a and PR-5, thereby inhibiting virus proliferation and movementby enhancement of the activity of some defensive enzyme.
%K 4(3H)-Quinazolinone
%K Schiff base
%K synthesis
%K antiviral activity
%U http://www.mdpi.com/1420-3049/12/12/2621