%0 Journal Article
%T Substituted N-Phenylpyrazine-2-carboxamides, Their Synthesis and Evaluation as Herbicides and Abiotic Elicitors
%A Martin Dole£¿al
%A Lenka T£¿mov¨¢
%A Diana Ke£¿etovi£¿ov¨¢
%A Ji£¿¨ª T£¿ma
%A Katar¨ªna Kr¨¢£¿ov¨¢
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12122589
%X The condensation of substituted pyrazine-2-carboxylic acid chlorides with ring-substituted anilines yielded five substituted pyrazine-2-carboxylic acid amides. Thesynthesis, and analytical, lipophilicity and biological data of the newly synthesizedcompounds are presented in this paper. The photosynthesis inhibition, antialgal activityand the effect of a series of pyrazine derivatives as abiotic elicitors on the accumulation offlavonoids in a callus culture of Ononis arvensis (L.) were investigated. The most activeinhibitor of the oxygen evolution rate in spinach chloroplasts was 6-chloro-pyrazine-2-carboxylic acid (3-iodo-4-methylphenyl)-amide (2, IC50 = 51.0 ¦Ìmol¡¤L-1). The highestreduction of chlorophyll content in Chlorella vulgaris was found for 5-tert-butyl-N-(4-chloro-3-methylphenyl)-pyrazine-2-carboxamide (3, IC50 = 44.0 ¦Ìmol¡¤L-1). The maximalflavonoid production (about 900%) was reached after a twelve-hour elicitation processwith 6-chloropyrazine-2-carboxylic acid (3-iodo-4-methylphenyl)-amide (2).
%K synthesis of pyrazinecarboxamides
%K photosynthesis inhibiting and antialgal activity
%K rest-harrow
%K flavonoid production
%K culture in vitro
%K lipophilicity.
%U http://www.mdpi.com/1420-3049/12/12/2589