%0 Journal Article
%T Synthesis of Novel N-(4-Ethoxyphenyl) Azetidin-2-ones and Their Oxidative N-Deprotection by Ceric Ammonium Nitrate
%A Aliasghar Jarrahpour
%A Maaroof Zarei
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12102364
%X It is shown that the N-(p-ethoxyphenyl) group on ¦Â-lactams can be oxidatively removed by ceric ammonium nitrate in good yield. Fourteen new N-(p-ethoxyphenyl)-2-azetidinones 8a-n were synthesized through standard [2+2] ketene-imine cycloadditions (Staudinger reaction). Treatment of these compounds with ceric ammonium nitrate yielded the N-dearylated 2-azetidinones 9a-n in good to excellent yields. The effects of solvent, molar equiv of CAN and different temperatures have been investigated and optimum conditions were established.
%K -Azetidinones
%K N-insubstituted ¦Â-Lactam
%K ceric ammonium nitrate
%K 2-Azetidinones
%K N-insubstituted ¦Â-Lactam
%K ceric ammonium nitrate
%K Staudinger reaction
%K p-ethoxyphenyl (PEP) group
%U http://www.mdpi.com/1420-3049/12/10/2364