%0 Journal Article
%T Solventless Lactam Synthesis by Intramolecular Cyclizations of ¦Á-Iminoester Derivatives under Microwave Irradiation
%A Fatima-Zohra Zradni
%A Jack Hamelin
%A Aicha Derdour
%J Molecules
%D 2007
%I MDPI AG
%R 10.3390/12030439
%X We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
%K Medium-sized ring lactams
%K imine alkylation
%K Schiff bases
%K microwave irradiation
%U http://www.mdpi.com/1420-3049/12/3/439