%0 Journal Article
%T Synthesis and Analgesic Activity Evaluation of Some Agmatine Derivatives
%A Hongxia He
%A Mengjia Liu
%A Zhibing Zheng
%A Ying Liu
%A Junhai Xiao
%A Ruibin Su
%A Chun Hu
%A Jin Li
%A Song Li
%J Molecules
%D 2006
%I MDPI AG
%R 10.3390/11060393
%X A series of N,NĄŻ-disubstituted-2-nitroethene-1,1-diamine and N,NĄŻ-disubstituted- NĄŻĄŻ-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.
%K Agmatine derivatives
%K synthesis
%K analgesic activity
%K blood-brain barrier
%K opioid dependence.
%U http://www.mdpi.com/1420-3049/11/6/393