%0 Journal Article %T Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents %A Mona A Mahran %A Samia William %A Fatem Ramzy %A Amira M Sembel %J Molecules %D 2007 %I MDPI AG %R 10.3390/12030622 %X A series of benzothiazol-2-yl-dithiocarbamates 3a-d along with their copper complexes 4a-c were synthesized via the reaction of suitable alkyl, aralkyl or heteroaryl halides with the sodium salt of benzothiazol-2-yl-dithiocarbamic acid, followed by complexation with copper sulphate. N-(4-Acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-benzothiazol-2-yl-acetamides 7a-c were synthesized by cyclization of the appropriate thiosemicarbazones 6a-c in acetic anhydride. Selected compounds were screened for in vitro schistosomicidal activity against Schistosoma mansoni at three different dosage levels (10, 50 and 100 ¦Ìg/ mL). Three of these products, 4a-c, showed schistosomicidal activity similar to praziquantel, with 100% worm mortality at 10 ¦Ìg/mL. These compounds would constitute a new class of potent schistosomicidal agents. %K Benzothiazole %K dithiocarbamate %K thiadiazole %K thiosemicarbazones %K schistosomicidal agents. %U http://www.mdpi.com/1420-3049/12/3/622