%0 Journal Article
%T Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423
%A Stanislav Gobec
%A Uro£¿ Urleb
%J Molecules
%D 2002
%I MDPI AG
%R 10.3390/70400394
%X A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between Lalanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogues 5 and 9. Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate 14. The scope and limitations of the synthetic strategies employed are discussed.
%K Muramyl dipeptide
%K analogues
%K phosphonamidates
%K phosphonates
%K immunomodulators
%U http://www.mdpi.com/1420-3049/7/4/394