%0 Journal Article
%T Use of Cyclic Allylic Bromides in the Zinc每Mediated Aqueous Barbier每Grignard Reaction
%A Gary W. Breton
%A John H. Shugart
%A Christine A. Hughey
%A Brian P. Conrad
%A Suzanne M. Perala
%J Molecules
%D 2001
%I MDPI AG
%R 10.3390/60800655
%X The zinc每mediated aqueous Barbier每Grignard reaction of cyclic allylic bromide substrates with various aldehydes and ketones to afford homoallylic alcohols was investigated. Aromatic aldehydes and ketones afforded adducts in good yields (66每90%) and with good diastereoselectivities. Non每aromatic aldehydes also reacted well under these conditions, but only poor yields were obtained with non每aromatic ketones. Regioselectivity was high when some substituted cyclic allylic bromides were investigated.
%K Barbier每Grignard reaction
%K aqueous reactions
%K organozinc
%K homoallylic alcohols
%U http://www.mdpi.com/1420-3049/6/8/655