%0 Journal Article
%T An Efficient Preparation of 1,2-Diamino-1-phenylheptane
%A S. Thennarasu
%A P. T. Perumal
%J Molecules
%D 2002
%I MDPI AG
%R 10.3390/70600487
%X A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time.
%K Piperidinone
%K Schmidt rearrangement
%K Hexahydrodiazapinone
%K Vicinal diamine
%U http://www.mdpi.com/1420-3049/7/6/487