%0 Journal Article
%T Facile Synthesis of 1,6-Bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane: a New Dinucleating Ligand
%A Gang-Chun Sun
%A Zhan-Hang He
%A Zhong-Jun Li
%A Xiao-Dong Yuan
%A Zhi-Juan Yang
%A Guo-Xi Wang
%A Liu-Fang Wang
%A Chang-Rang Liu
%J Molecules
%D 2001
%I MDPI AG
%R 10.3390/61201001
%X A convenient three-step preparation of the dinucleating ligand, 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane (3) starting from 2,6-bis(hydroxymethyl)-4-methylphenol (4) is reported. Compound 4 was partially oxidized with preactivated manganese dioxide to form compound 5, which was converted to 2-hydroxy-3-chloromethyl-5-ethylbenzaldehyde (6) with conc.HCl/EtOH. Compound 6 in turn reacted with N,NĄŻ-bis (2-furyl)-1,2-diaminoethane (7) in the presence of K2CO3 in ethanol to give the title compound 3. No protecting groups were required in the whole process and the conditions were mild.
%K Synthesis
%K Dinucleating ligand
%K 2
%K 5-Diazahexane derivative
%K Partial oxididation
%K Manganese dioxide
%U http://www.mdpi.com/1420-3049/6/12/1001