%0 Journal Article
%T Facile Synthesis of (R,R) and of (R,S) Tricarballylic Acid Anhydride and Imide Derivatives
%A Abdel-Sattar S. Hamad Elgazwy
%J Molecules
%D 2000
%I MDPI AG
%R 10.3390/50400665
%X The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl)succinic anhydride 6 with (R)-(¦Á)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(¦Á)-Methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9s and 1-[(R)-(¦Á)-methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9a was isolated as an intermediate under the reaction conditions. This diastereomeric mixture 9s/9a was also prepared by a different route via reaction of 1-(chloroformyl)propane-2,3-dicarboxylic acid anydride 12 with (R)-(¦Á)-methylbenzylamine in the presence of DMA at 0oC for 24 hrs.
%K Fumonisin
%K AAL Toxin TA
%K Actinoplanic acid
%K Diastereomers of Tricarballylic acid
%K Sphingosine analogs
%U http://www.mdpi.com/1420-3049/5/4/665