%0 Journal Article
%T Synthesis and 1,3-Dipolar Cycloaddition Reactions of Chiral Maleimides
%A Vladimir Ondrus
%A Lubor Fisera
%J Molecules
%D 1997
%I MDPI AG
%R 10.3390/feb97p5
%X New routes to the synthesis of various novel chiral maleimides are described. The oxabicyclic anhydride 2 readily available exo-Diels-Alder adduct of furan and maleic anhydride was used as a vehicle, which in turn reacted with hydrochlorides of amino acids 3a-f in the presence of Et3N with release of furan to give the requisite novel chiral imides 4a-f in good to moderate yields. The stereoselectivity of 1,3-dipolar cycloaddition of nitrile oxides with prepared chiral imides 4a-f is investigated.
%K Chiral maleimides
%K 1
%K 3-dipolar cycloadditions
%K nitrile oxides
%K stereoselectivity
%U http://www.mdpi.com/1420-3049/2/2/49