%0 Journal Article
%T The acute lethality and endocrine e ect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo<br>The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish （ Carassius auratus ） in vivo
%A YANG Yongbin
%A LIU Zhengtao
%A ZHENG Minghui
%A ZHAO Yanyan
%A WANG Liang
%A SUN Wei
%A XIAO Feng
%A <br>YANG Yongbin
%A LIU Zhengtao
%A ZHENG Minghui
%A ZHAO Yanyan
%A WANG Liang
%A SUN Wei
%A XIAO Feng
%J 环境科学学报(英文版)
%D 2008
%I 
%X 1,2,3,7,8-PeCDD was administrated to juvenile goldfish (Carassius auratus) by peritoneal injections to explore the acute lethality and endocrine effects of 1,2,3,7,8-PeCDD in vivo. The value of acute median lethal dosage (LD50) of 1,2,3,7,8-PeCDD was determined in acute lethality tests. The endocrine effect of 1,2,3,7,8-PeCDD, whose exposed concentrations were determined based on the LD50 (1.84 mg/kg), was studied by measuring the plasma vitellogenin (Vtg) content in juvenile male goldfish with enzyme-linked immunosorbent assays (ELISA). Due to its significant induction of the plasma Vtg after one week's exposure in vivo in the 1/2 LD50 and LD30 groups,1,2,3,7,8-PeCDD might be one of the important contributors to the estrogenic effect of PCDDs in the environment. The values of 1/2 LD50 and LD30 were within the range of the effective dosages of 1,2,3,7,8-PeCDD, indicating that there was a certain relationship between the estrogenic effective dosages and the LD50.
%K 1
%K 2
%K 3
%K 7
%K 8-PeCDD
%K goldfish
%K endocrine effect
%K vitellogenin (Vtg)
%K acute lethality
%K ELISA<br>金鱼
%K 致命性
%K 卵黄蛋白原
%K 内分泌
%K 毒理学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=6CB1530875F53489BF1E81BD87B7F5E6&aid=501F53DDCA5E2C595E7C30FC6AE4F741&yid=67289AFF6305E306&vid=A04140E723CB732E&iid=0B39A22176CE99FB&sid=C812B90E96151014&eid=E2E0FBFE4D7EFB94&journal_id=1001-0742&journal_name=Journalofenvironmentalsciences(China)&referenced_num=0&reference_num=41