%0 Journal Article
%T An Improved Synthesis of Homocitrate
%A Zeng-Chun Li
%A Ji-Qing Xu
%J Molecules
%D 1998
%I MDPI AG
%R 10.3390/30200031
%X Monoethyl malonate (1) and tert-butyl alcohol are esterified by catalysis with dicyclohexylcarbodiimide and 4-dimethylaminopyridine to yield ethyl t-butyl malonate (2). The ethoxymagnesio derivative (3) of the ester is condensed with b-carbomethoxypropionyl chloride to give the triester (4), which is decomposed by heating under vacuum in the presence of b-naphthalensulfonic acid to give ethyl methyl ¦Â-ketoadipate (5). Compound 5 is reacted with hydrogen cyanide,followed by hydrolysis of the cyanohydrin to give the free acid (6). Compound 6 is converted to homocitrate (7) by the use of an improved procedure.
%K Homocitrate
%K synthesis
%U http://www.mdpi.com/1420-3049/3/2/31