%0 Journal Article
%T Biological transformation, kinetics and dose-response assessments of bound musk ketone hemoglobin adducts in rainbow trout as biomarkers of environmental exposure<br>
%A M A Mottale
%A J H Zimmerman
%A T W Moy
%A <br>
%J 环境科学学报(英文版)
%D 2008
%I 
%X Low levels (ng/g) of musk ketone (MK),used as a fragrance additive in the formulation of personal care products,are frequently detected in the water and other environment.Thus,aquatic organisms can be continuously exposed to MK.In this study,kinetics and dose-response assessments of 2-amino-MK (AMK) metabolite,bound to cysteine-hemoglobin (Hb) in rainbow trout,formed by enzymatic nitro-reduction of MK have been demonstrated.Trout were exposed to a single exposure of 0.010,0.030,0.10,and 0.30 mg MK/g fish...
%K biotransformation
%K kinetics
%K hemoglobin adducts
%K dose-response
%K nitro musks
%K biomarker
%K fish<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=A7CA601309F5FED03C078BCE383971DC&jid=6CB1530875F53489BF1E81BD87B7F5E6&aid=849E9E8254F4771ED6A0D13CB7FD7E95&yid=67289AFF6305E306&vid=A04140E723CB732E&iid=DF92D298D3FF1E6E&sid=2D207DE75533FA7E&eid=BEBF2238C7F1C1F1&journal_id=1001-0742&journal_name=Journalofenvironmentalsciences(China)&referenced_num=0&reference_num=7