%0 Journal Article
%T Synthesis and Biological Evaluation of 14 -Methoxy Digitalis Derivatives
%A M. Gobbini
%A N. Almirante
%A A. Cerri
%A G. Padoani
%A P. Melloni
%J Molecules
%D 1998
%I MDPI AG
%R 10.3390/30100020
%X The synthesis and biological evaluation of 14¦Â-methoxy derivatives of digitoxigenin and of other digitalis-like compounds are reported. These compounds have a 14¦Â-oxygen, which can be a hydrogen bonding acceptor, as is the case of 14¦Â,15¦Â-epoxide derivatives, but not a hydrogen bonding donor as is the case of 14¦Â-hydroxy derivatives. All the new 14¦Â-methoxy derivatives show a considerable reduced binding affinity on Na+,K+-ATPase when compared with the 14¦Â-hydroxy analogues and also with the 14¦Â,15¦Â-epoxy derivatives. These results could mean that the digitalis receptor does not permit the presence of a bulky substituent in the 14¦Â region, even of relatively small volume like the methyl group
%K 14b-Methoxy digitalis derivatives
%K binding affinity
%K Na+
%K K+-ATPase
%U http://www.mdpi.com/1420-3049/3/1/20