%0 Journal Article
%T Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid ¨C An N(9)-Functionalized 7-Deazapurine
%A Helmut Rosemeyer
%J Molbank
%D 2009
%I MDPI AG
%R 10.3390/m590
%X Regioselective N-alkylation of 4-chloro-2-methoxy-7H-pyrrolo[2,3- d]pyrimidine (6) with ethyl 3-bromopropionate under liquid-liquid phase-transfer reactionconditions gave the ester 7a. Its saponification yielded the acid 7b. The logP values of a series of N(9)-functionalized purines and purine isosteres were calculated.
%K 7-Deazapurines
%K pyrrolo[2
%K 3-d]pyrimidines
%K functionalization
%K phase-transfer alkylation
%K logP values
%U http://www.mdpi.com/1422-8599/2009/1/M590