%0 Journal Article
%T Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell<br>两面针红外指纹图谱与抗癌活性的谱效研究
%A MAOXiao-Li
%A QIN Yu
%A CAI Juan
%A ZHENG Juan-Mei
%A YE Yue-Hu
%A liuhuagang
%A huangshushi
%A <br>毛晓丽
%A 覃禹
%A 蔡鹃
%A 郑娟梅
%A 叶月华
%A 刘华钢
%A 黄庶识
%J 红外与毫米波学报
%D 2013
%I Science Press
%X Mathematical expression was established for evaluating anticancer efficacy of samples of Z. nitidum to human tumor cells based on their infrared fingerprints. Chloroform extracts of the root of Z. nitidum from different habitats in China were used as subject samples to do anticancer experiments on two strains of human tumor cells, 7901 and Hela cells. Meanwhile, their fingerprints of infrared spectra were obtained. Screening arguments of backward elimination method was adopted to establish the spectra-effect correlation between infrared fingerprint and pharmacology data. The results showed that deviations of the predictive values from the true values were within ?10% for the two kinds of tumor cells, suggested that there was close correlation between infrared fingerprint and biological activity of Z. nitidum. The model implied that alkaloids in Z. nitidum have main effect on tumor cells.
%K Zanthoxylum nitidum(Roxb
%K )DC
%K Infrared fingerprint
%K Spectrum-effect relationships
%K Backward Variable Elimination<br>两面针
%K 红外指纹图谱
%K 谱效关系
%K 后退消元法
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=1319827C0C74AAE8D654BEA21B7F54D3&jid=D3B4F771D1A06062008B4D0A2EF05996&aid=575970AF4D20326379CCF9A1AC1BA255&yid=FF7AA908D58E97FA&vid=9971A5E270697F23&iid=38B194292C032A66&sid=C753EB8AC8F551B9&eid=6700D0D256586E73&journal_id=1001-9014&journal_name=红外与毫米波学报&referenced_num=0&reference_num=0